Enchanter’s nightshade usually favours loose soils rich in leaf litter, conditions in which it can be forked out with little difficulty, although it may be hard to remove all traces of the weed at a single attempt.
In areas where it is not so easy to fork out by hand, a heavy mulch of leaf litter will encourage the weed to root into the loose layer from which it can be more easily removed.
Where the weed is established clear of garden plants, a glyphosate-based weedkiller (e.g. Scotts Roundup, Bayer Garden Rootkill Weedkiller or Doff Knockdown Super Strength Glyphosate Weedkiller) can be applied as an overall spray. This is best done from mid-summer onwards, when the weed is coming into flower, or later, but before the foliage begins to die down in autumn.
If garden plants such as primulas, ferns and other woodland plants are nearby it is safer to spot treat with a ready-to-use spray or gel application (Scotts Roundup Gel). The full effects of glyphosate on weeds can take three or four weeks to develop. As it is inactivated on contact with the soil, it can be used in areas where there are underlying tree or shrub roots nearby.
Occasionally, enchanter’s nightshade may be encountered amongst established shrubs or under hedgerows in moist soils. In these situations Bayer Garden Path & Drive Weedkiller and Scotts Weedol Pathclear products containing glyphosate/diflufenican and can be applied once a season to natural surfaces where no plants are to be grown, and can also be applied under and around established woody trees and shrubs. This product kills off existing small green growth and prevents or checks developing growth. Check manufacturer’s recommendations before use to avoid damaging sensitive plants.
Inclusion of a weedkiller product does not indicate a recommendation or endorsement by the RHS. It is a list of products currently available to the home gardener.
Weedkillers for gardeners (Adobe Acrobat pdf document outlining weedkillers available to gardeners; see sections 4 and 5)
Chemicals: using a sprayer
Chemicals: using safely and effectively
Chemicals: using spot and broad-scale weedkillers
Weeds: non-chemical control